Clinical trials

The study is designed to test the hypothesis that the same dose of TXA prior to delivery or pre-cord clamp will be sufficient to achieve hemorrhage prevention targets and define dosing schema for intravenous (IV) and intramuscular (IM).

In this multi-site, observational prospective study of pregnant people and their infants, we will assess the timing of pregnancy diversification of the vaginal microbiome. We will also explore the driving hormonal and immunological influences on vaginal microbiome diversification as well as the mother to infant microbiome transfer based on the diversification of the vaginal microbiome.

The purpose of this study is to create a repository of coded specimens and data to support and advance future research studies for pregnancy-related disorders.

The study is designed to use ultrasound to image the pelvic floor muscles before and after delivery to determine what characteristics can lead to muscle injury during a vaginal delivery.

The Yaari Extractor Investigational Device is intended for treatment of shoulder dystocia (SD). The purpose is to create a more effective and controlled response to SD compared to the current standard of care. Furthermore, to decrease risks and complications to mother and baby.

The objective of this study is to analyze the relationships between maternal SARS-CoV-2 infection, placental pathology/biology, and offspring neurodevelopmental outcomes.

Research has shown that for women who are undergoing pelvic radiation therapy, fatigue is a common side effect. Fatigue that occurs during radiation therapy can make it harder to perform daily living activities. While there are studies that recommend exercise as a treatment for fatigue in cancer patients and survivors, there are currently no studies that focus on the role of exercise for women undergoing pelvic radiation therapy. The purpose of this study is to see if incorporating an activity coaching program is helpful in improving treatment-related fatigue for women undergoing pelvic radiation therapy for endometrial cancer.

This is single arm-triplet therapy with Atezolizumab, bevacizumab, and memantine in treatment of hepatocellular carcinoma. This study assesses the objective response rate (ORR) at 6 months in patients with unresectable, locally advanced or metastatic HCC. The Objective Response Rate (ORR) in terms of tumor shrinkage (by RECIST v1.1 criteria) is obtained during the treatment with protocol therapy.

As part of a multidisciplinary cancer screening program that is being conducted by the Saville Cancer Screening and Prevention Center and Department of Occupational Health within the Inova Health System, the purpose of this research study is to generate preliminary data on the clinical impact of investigational cancer screening modalities in career and volunteer firefighters.

Aims include evaluating the clinical impact and performance of cancer detection tools, the diagnostic follow-up and healthcare utilization prompted by use of each investigational tool, and assessments of anxiety and feasibility of implementation related to the screening protocols in participants. It is anticipated that results from this pilot will support the development of future firefighter cancer screening programs and serve as a research framework that can be adopted and tested within other health systems in partnership with the local fire jurisdictions in their catchment area, with the ultimate goal of identifying the risks and benefits of these tools for early cancer detection in the firefighter population.

This study receives partial funding from the Virginia Department of Health.

This is a two-arm, randomized, double blind, placebo-controlled study of Optune (Tumor Treating Fields at 200 kHz) to the brain concomitant with maintenance Temozolomide (TMZ) chemotherapy agent  and pembrolizumab compared to Optune concomitant with maintenance TMZ and placebo in newly diagnosed Glioblastoma (GBM) patients. The primary objective of the study is to evaluate the Overall Survival (OS).