Clinical trials

Randomized Phase III Trial of Neoadjuvant Immunotherapy with Response-Adapted Treatment Versus Standard-Of-Care Treatment for Resectable Stage III/IV Cutaneous Squamous Cell Carcinoma

A Phase 2 Randomized, Double-Blind, Placebo- and Active-Comparator- Clinical Study of V940 (mRNA-4157) Plus Pembrolizumab v Placebo Plus Pembrolizumab in Participants With First-Line Advanced Melanoma (MKV940-012)

HERTHENA-Breast-01: A Phase 1b/2, Multicenter, Open label, Dose-Finding Study to Evaluate the Safety and Antitumor Activity of Patritumab Deruxtecan in Participants with HER2 Positive Unresectable Locally Advanced Breast Cancer or Metastatic Breast Cancer

Phase II Interventional Study using Atorvastatin to Reduce Cisplatin-Induced Hearing Loss among Individuals with Head and Neck Cancer

To evaluate the effect of early detection of cardiac structural and functional abnormalities associated with iron overload-related cardiotoxicity followed by early intervention in patients with sickle cell disease (SCD) as measured by incidence of hospitalization and length of stay for SCD-related complications. 

XB010 is an antibody-drug conjugate (ADC) targeting 5T4 with a monomethyl auristatin E (MMAE)
payload. ADCs and immune checkpoint inhibitors (ICIs) have shown efficacy in the treatment of
various cancers as monotherapies and in ADC-ICI combinations. Because of the potential of
pembrolizumab to enhance the anticancer effect of XB010, combination therapy with pembrolizumab
may also be explored.

Heart failure is a condition where the heart muscle cannot pump blood effectively to meet the body's needs. Among children and adults with complex heart disease (congenital or acquired), heart failure is the main cause of death or heart transplantation. The purpose of the study is to evaluate heart failure progression among children from multiple sites around the world, to find the best ways to manage the disease and work towards long and healthy lives in this population.

Imaging plays an important role in diagnosis and evaluation of heart diseases (congenital or acquired) as well as follow-up. The purpose of this study is to collect and report variations in imaging modalities in pediatric heart diseases in order to help standardize the care of patients.

Iodinated contrast media (ICM) are substances containing iodine that are used in medical imaging procedures (such as X-rays, computed tomography [CT] scans, and cardiac catheterization with angiography). ICM are known to have toxic effects, however, their effect on thyroid function has not been fully studied. The purpose of the study is to determine the extent of thyroid dysfunction that follows ICM exposure in high-risk pediatric patients.

Cardiac catheterization is a medical procedure that involves inserting a thin, flexible tube (catheter) into a blood vessel and threading it into the heart. Cardiac catheterization procedures may require access to the upper systemic chamber (left atrium) or lower systemic chamber (left ventricle) of the heart. Historically it was done using the artery in the groin (femoral artery), and now it is often approached via the femoral vein, using a puncture across the atrial wall (trasseptal puncture) to access the left side of the heart from the right side. The primary outcome is to assess transseptal puncture success and assess puncture related adverse events.