Clinical trials

Atrial fibrillation is a condition where the upper chambers of the heart (atria) have abnormal electrical signals, which can disrupt blood flow and heart function. Atrial fibrillation in patients less than 35 years of age is rare and known as early-onset atrial fibrillation. Initial data indicate specific genetic anomalies in patients with early-onset atrial fibrillation. In this study we perform genetic assessment of children with early onset atrial fibrillation to better characterize the presentation and outcomes of this disorder.

A Randomized Controlled Multicenter Clinical Trial Evaluating Intact Fish Skin Graft and Standard of Care versus Standard of Care alone in Nonhealing Venous Leg Ulcers

The primary objective of the study is to assess the clinical efficacy of selatogrel when self-administered upon occurrence  of symptoms suggestive of an acute myocardial infarction (AMI) in subjects at risk of having a recurrent AMI.

The purpose of this research is to investigate the safety and effectiveness of the combination of fianlimab and cemiplimab as compared with the combination of two medications, relatlimab and nivolumab, commercialized under the brand name Opdualag™ for treating melanoma. 

This study assesses how blood cell growth patterns (clonal hematopoiesis), relates to heart health or cardiovascular disease (CVD) after treatment in patients with Hodgkin lymphoma. In some patients, cancer treatment at a young age may lead to later complications, including problems with heart health. Checking for blood cell growth patterns called therapy-related clonal hematopoiesis (t-CH) can help predict who might be at risk for heart health problems after Hodgkin lymphoma treatment. If doctors know who may be at greater risk for developing later heart complications, then they can more closely monitor those patients to prevent or detect heart complications early.

By establishing an acupuncture treatment regimen, this research will contribute to evidence-based guidelines for incorporating acupuncture as a non-pharmacologic intervention in supportive cancer care, with the potential to enhance quality of life outcomes among men with prostate cancer experiencing treatment-induced hot flashes.

The study is a pilot feasibility study of a randomized controlled trial. A total of 24 study participants will be randomized 1:1 into the intervention arm (immediate acupuncture, IA) or into the wait-list attention control arm (delayed acupuncture, DA), yielding 12 participants per arm, using simple randomization. Participants will be followed for 22 weeks.  

The primary aim of this study is to evaluate the feasibility and acceptability of the study procedures, recruitment strategies, and intervention delivery in a pilot randomized controlled trial investigating an acupuncture intervention for anti-androgen-induced hot flashes in men with prostate cancer. 

The purpose of this study is to determine if ABBV-400 given alone (monotherapy) will delay relapse in and potentially cure subjects with colorectal cancer who have positive ctDNA test after surgical removal of tumor and chemotherapy (adjuvant therapy).  

ctDNA stands for "circulating tumor" DNA, which means that cancer cells can be detected in your body before, during or after therapy. Patients with detectable ctDNA after surgery and chemotherapy have a higher risk of recurrence compared with ctDNA negative patients.  

Currently after adjuvant therapy, patients do not receive further treatment but instead undergo tumor imaging scans such as CT/MRI to assess for tumor recurrence. 

NRG-CC011 is a clinical study trying to determine if computerized cognitive training can improve cancer-related cognitive impairment including the ability to concentrate, learn new things, remember, and make decisions that affect daily life in breast cancer survivors. We are doing this study to determine the usefulness of computerized cognitive training for cancer-related cognitive impairment and to compare different approaches to cognitive training. The usual approach for participants who are not in a study is to get advice about cancer-related cognitive impairment from their doctors.

The goal of this trial is to determine if a digital mindfulness meditation-based intervention program can improve the mental health and well-being among younger breast cancer survivors with elevated symptoms of depression. Mindfulness meditation programs provided in person have been shown to be helpful for younger breast cancer survivors. This study will compare different digital approaches for mindfulness training to see which is the most effective.

The purpose of this study is to assess the safety and efficacy of neoadjuvant carboplatin and mirvetuximab soravtansine in participants with folate receptor alpha (FRα) -expressing advanced-stage serous epithelial ovarian, fallopian tube or primary peritoneal cancer (EOC).Mirvetuximab Soravtansine (MIRV) is an investigational antibody drug conjugate designed to selectively kill cancer cells. The antibody (protein) part of MIRV targets tumors by delivering a cell-killing drug to cancer cells carrying a protein called folate receptor alpha (FRα). This is a single arm study in adult participants with advanced-stage Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) III-IV FRα-expressing serous EOC.